Product specifications
| Product Name | CD-Screen-IEC HPLC Column, 3 µm, 150 × 4 mm |
|---|---|
| Part Number | CDS-IEC-1504-03 |
| Selector / Type | Ion-exchange-type CD-Screen |
| Stationary Phase | Specialized phase for ionic cyclodextrin derivatives |
| Particle Size | 3 µm |
| Column Length | 150 mm |
| Internal Diameter | 4 mm |
| Quality | Analytical device |
Technical overview
The CD-Screen-IEC column was developed for separation of ionic cyclodextrin derivatives. A representative application area is sulfobutylether-beta-cyclodextrin (SBECD), where a suitably developed method may support degree-of-substitution assessment, component-distribution analysis and determination of selected impurities.
Relevant abbreviations include SBECD for sulfobutylether-beta-cyclodextrin, BCD for beta-cyclodextrin, HBSA for hydroxybutanesulfonic acid and DBSA for 4,4′-oxybutane-1,1′-disulfonic acid. Depending on the sample and validated method, these impurities may be separated from cyclodextrin components. Modified methods may also be investigated for degradation-product quantification.
No single method should be assumed to work automatically for every SBECD material, substitution pattern, formulation or impurity profile. Mobile phase, detector, temperature, sample preparation, flow and system-suitability requirements must be optimized and validated for the intended use.
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